Perioperative medicine & outcomes
Three-year Survival Outcomes of Patients With Enhanced Recovery After Surgery Versus Conventional Care in Laparoscopic Distal Gastrectomy: The GISSG1901 Randomized Clinical Trial
Authors' conclusion
Patients undergoing ERAS LDG had fewer overall complications, shorter hospital stays, decreased medical expenses, and improved 3-year OS and DFS rates, particularly in cases with stage III gastric cancer.
Study context
- Population
- Patients with locally advanced lower gastric adenocarcinoma undergoing laparoscopic distal gastrectomy (LDG), 13 centres in China, 2019–2020
- Participants
- 527 patients · 13 centres
- Comparison
- ERAS vs conventional care in laparoscopic distal gastrectomy
- ERASn = 186
- Conventionaln = 184reference
- Primary endpoint
- Overall survival (OS) and disease-free survival (DFS)
- Follow-up
- 3 years
Methodological detailsmulticentre
- Multicentre
Primary result
As reported in the abstract
Values · 3 years
3-year DFS
- ERAS vs Conventional: log-rank P = 0.025
- ERAS vs Conventional: log-rank P = 0.027
Secondary outcomes
3-year OS and DFS, stage III (subgroup)
log-rank P = 0.046
3-year DFS
| Outcome | P value |
|---|---|
| 3-year OS and DFS, stage III (subgroup) | log-rank P = 0.046 |
- 3-year overall survival (OS) and disease-free survival (DFS), stage III (subgroup): per-group value = 3-year OS
3-year OS and DFS, stage I and II (subgroup)
- Similar between groups; stage I OS P = 0.901, DFS P = 0.859; stage II OS P = 0.421, DFS P = 0.459
Postoperative hospital stay, interval before adjuvant chemotherapy, medical expenses
- Shorter hospital stay and interval before adjuvant chemotherapy, lower medical expenses with ERAS (reported previously)
Safety
Overall complications
P = 0.037
Original publication
Three-year Survival Outcomes of Patients With Enhanced Recovery After Surgery Versus Conventional Care in Laparoscopic Distal Gastrectomy: The GISSG1901 Randomized Clinical Trial. Ann Surg. Published 11 December 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →