Pediatric anesthesia & critical care
Transnasal Humidified Rapid Insufflation Ventilatory Exchange Augments Oxygenation in Children With Juvenile Onset Recurrent Respiratory Papillomatosis During Surgery: A Prospective Randomized Crossover Controlled Trial
Primary result · Apnea timeResult — go to the resultMean difference 5.0 95% CI 4.4–5.6Authors' conclusion
Our findings demonstrate that THRIVE safely increased the apnea time among children with JORRP undergoing surgery and decreased the rate of carbon dioxide increase.
Study context
- Population
- Children aged 2 to 12 years with juvenile onset recurrent respiratory papillomatosis (JORRP), abnormal airways and ASA II–III undergoing surgery under GA (tubeless anesthesia)crossover
- Participants
- 28 children
- Comparison
- Apnea with transnasal humidified rapid insufflation ventilatory exchange (THRIVE) vs apnea without oxygen supplementation
- Primary endpoint
- Apnea time (from withdrawal of intubation to reintubation and resumption of controlled ventilation)
Methodological detailsprospective, 5-minute washout
- Prospective
- 5-minute washout
Primary result
Apnea time
Mean difference
5.0
95% CI 4.4–5.6
P < 0.001
By group
THRIVE vs Control
mean difference 5.0 (95% CI 4.4–5.6); P < 0.001
As reported in the abstract
Secondary outcomes
mm Hg min −1
| Outcome | THRIVE | Control | Mean difference (95% CI) | P value | |
|---|---|---|---|---|---|
| Rate of CO2 change, aged 2 to 5 years (subgroup) | 3.22 (IQR 2.92–3.76) | 6.29 (IQR 5.19–7.4) | 3.09 (2.27–3.67) | P < 0.001 | |
| Rate of CO2 change, aged 6 to 12 years (subgroup) | 3.38 (IQR 2.64–4.0) | 4.76 (IQR 3.7–6.2) | 1.63 (0.75–2.56) | P < 0.001 | |
| Minimum SpO2 during apnea | 19.7 (14.8–22.6) | P < 0.001 | |||
| −100102030Difference (linear scale) |
Original publication
Transnasal Humidified Rapid Insufflation Ventilatory Exchange Augments Oxygenation in Children With Juvenile Onset Recurrent Respiratory Papillomatosis During Surgery: A Prospective Randomized Crossover Controlled Trial. Anesth Analg. Published 19 May 2023. doi:10.
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