Early Restrictive vs Liberal Oxygen for Trauma Patients: The TRAUMOX2 Randomized Clinical Trial
Authors' conclusion
In adult trauma patients, an early restrictive oxygen strategy compared with a liberal oxygen strategy initiated in the prehospital setting or on trauma center admission for 8 hours did not significantly reduce death and/or major respiratory complications within 30 days.
Study context
- Population
- Adult trauma patients with full trauma team activation and anticipated hospital stay ≥24 hours, 15 prehospital bases and 5 major trauma centres in Denmark, the Netherlands and Switzerland1,508 completed
- Participants
- 1,979 patients
- Comparison
- Early 8-h restrictive vs liberal oxygen strategy
- Restrictive oxygenn = 733
- Liberal oxygenn = 724reference
- Primary endpoint
- Composite of:
- Death
- Major respiratory complications
- Follow-up
- 30 days
Methodological detailsmulticentre, blinded outcome assessment
- Multicentre
- Blinded outcome assessment
Primary result
As reported in the abstract
Each group vs liberal oxygenOdds ratio (95% CI)P value
Restrictive oxygen
1.01(0.75–1.37)
P = 0.94Each group vs liberal oxygenAbsolute difference, percentage points (95% CI)
Restrictive oxygen
0.56(−2.70 to 3.82)
Secondary outcomes
Death and major respiratory complications (each component, key secondary) · 30 days
- No significant differences between groups for each component
Safety
Atelectasis
- Atelectasis: Other adverse and serious adverse events similar across groups
Original publication
Early Restrictive vs Liberal Oxygen for Trauma Patients: The TRAUMOX2 Randomized Clinical Trial. JAMA. Published 11 February 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →