Treatment of positive catheter tip culture without bloodstream infections in critically ill patients. A case-cohort study from the OUTCOMEREA network
Authors' conclusion
Antimicrobial therapy was not associated with decreased risk of subsequent infection or death in short-term catheter tip colonization in critically ill patients.
Study context
- Population
- Intensive care unit (ICU) patients with positive catheter tip culture without bloodstream infection, 29 centres of the OUTCOMEREA network
- Participants
- 427 patients · 150 matched pairs
- Exposure
- Treated vs Non-treated
- Treatedn = 150
- Non-treatedn = 150reference
- Outcome
- Subsequent infections and mortality
- Follow-up
- 30 days
Methodological detailsretrospective analysis of prospectively collected data, propensity-score matched 1:1, multicentre
- Retrospective analysis of prospectively collected data
- Propensity-score matched 1:1
- Multicentre
Main finding
As reported in the abstract
Treated vs Non-treatedEstimate (95% CI)P value
Subsequent infection up to Day-30
sHR 1.08(0.62–1.89)
P = 0.7830-day mortality
HR 0.89(0.45–1.74)
P = 0.73- Subsequent infections in matched population
- 30 (10%)
- Deaths within 30 days in matched population
- 62
Observational data: associations, not effects.
Original publication
Treatment of positive catheter tip culture without bloodstream infections in critically ill patients. A case-cohort study from the OUTCOMEREA network. Intensive Care Med. Published 24 June 2024. doi:10.
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