Neuroanesthesia & neurocritical care
Trending Ability of End-Tidal Capnography Monitoring During Mechanical Ventilation to Track Changes in Arterial Partial Pressure of Carbon Dioxide in Critically Ill Patients With Acute Brain Injury: A Monocenter Retrospective Study
Authors' conclusion
Our results question the performance of trending ability of Et co2 to track changes in Pa co2 in a population of critically ill patients with acute brain injury. Changes in Et co2 largely failed to follow changes in Pa co2 in both direction (ie, low concordance rate) and magnitude (ie, large radial LOA).
Study context
- Population
- Critically ill patients with acute brain injury on mechanical ventilation with continuous Et co2 monitoring and 2 or more arterial gases3,923 paired ΔEt co2 and ΔPa co2
- Participants
- 255 patients
- Exposure
- End-tidal capnography trends vs PaCO2 trends
- Outcome
- Agreement between trends in Et co2 and PaCO2 (Bland-Altman, 4-quadrant concordance, polar plot)
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
Agreement and trending ability of Et co2 vs PaCO2
Mean bias by Bland-Altman analysis
−8.1
95 CI, −7.9 to −8.3; mm Hg
Directional concordance rate
55.8%
Mean radial bias by polar plot
−4.4°
95% CI −5.5 to −3.3
Radial limit of agreement (LOA) (radial LOA 95% CI ±1.9°)
±62.8°
Observational data: associations, not effects.
Original publication
Trending Ability of End-Tidal Capnography Monitoring During Mechanical Ventilation to Track Changes in Arterial Partial Pressure of Carbon Dioxide in Critically Ill Patients With Acute Brain Injury: A Monocenter Retrospective Study. Anesth Analg. Published 15 June 2023. doi:10.
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