Cardiac arrest & resuscitation
Ubiquitin C‐terminal hydrolase L1 after out‐of‐hospital cardiac arrest
Authors' conclusion
Concentrations of UCH-L1 in serum were higher in patients with unfavourable outcome than in those with favourable outcome. However, the ability of UCH-L1 to predict unfavourable outcome after OHCA was only moderate and not superior to that of NSE.
Study context
- Population
- Out-of-hospital cardiac arrest (OHCA) patients treated in 21 Finnish ICUs in 2010–2011
- Participants
- 249 patients · 21 Finnish ICUs
- Comparison
- Serum UCH-L1 vs neuron-specific enolase (NSE) for predicting unfavourable outcome at 12 months
- Primary endpoint
- Prediction of unfavourable outcome (cerebral performance category 3-5) by AUROC
- Follow-up
- 12 months
Methodological detailsdiagnostic accuracy, post-hoc analysis, multicentre
- Diagnostic accuracy
- Post-hoc analysis
- Multicentre
Primary result
As reported in the abstract
AUROC for unfavourable 12-month outcome
| Group | AUC at 24 h | AUC at 48 h |
|---|---|---|
| UCH-L1 | 0.66 (95% CI 0.60-0.73) | 0.66 (0.59-0.74) |
| NSE | 0.66 (0.59-0.73) | 0.72 (0.65-0.80) |
AUC at 24 h
UCH-L10.66 (95% CI 0.60-0.73)
NSE0.66 (0.59-0.73)
AUC at 48 h
UCH-L10.66 (0.59-0.74)
NSE0.72 (0.65-0.80)
- UCH-L1 vs NSE: P = 0.82 — not different
- UCH-L1 vs NSE: P = 0.23 — not different
Further findings
Serum UCH-L1 concentration, unfavourable vs favourable outcome · 24 h
P < 0.001
Serum UCH-L1 concentration, unfavourable vs favourable outcome · 48 h
P < 0.001
Original publication
Ubiquitin C‐terminal hydrolase L1 after out‐of‐hospital cardiac arrest. Acta Anaesthesiol Scand. Published 28 April 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →