Pediatric anesthesia & critical care
Ultrasound-guided bilateral serratus plane block versus thoracic paravertebral block following minimally invasive pectus excavatum repair in children: A randomized controlled non-inferiority study.
Primary result · NRS pain scoreResult — go to the resultEffect size 0.027 95 % CI −0.42 to 0.47Authors' conclusion
Compared with TPVB, SAPB provides non-inferior analgesia for children undergoing minimally invasive pectus excavatum repair surgery.
Study context
- Population
- Children aged 7–16 years undergoing minimally invasive pectus excavatum repair, West China Hospital of Sichuan University
- Participants
- 74 children
- Comparison
- Bilateral serratus anterior plane block (SAPB) vs thoracic paravertebral block (TPVB) after induction
- SAPBn = 37
- TPVBn = 37reference
- Primary endpoint
- Pain scores (numerical rating scale (NRS))
- Follow-up
- 24 h postoperatively
Methodological detailsnon-inferiority
- Non-inferiority
Primary result
NRS pain score
Effect size
0.027
95 % CI −0.42 to 0.47
P = 0.905
By group
SAPB
1
Median · IQR 1.0–2.0
TPVB
1
Median · IQR 0.5–2.0
As reported in the abstract
Further findings
| Outcome | SAPB | TPVB |
|---|---|---|
| Plasma ropivacaine concentration · 10, 30 and 60 min post-injection | 0.44, 0.56, 0.66 (unspecified 0.21, 0.23, 0.29) μg mL-1 | 1.18, 1.17, 1.13 (unspecified 0.39, 0.30, 0.26) μg mL-1 |
Plasma ropivacaine concentration · 10, 30 and 60 min post-injection
- Lower in SAPB at all measured time points
Safety
Hypotension
P = 0.018
Original publication
Ultrasound-guided bilateral serratus plane block versus thoracic paravertebral block following minimally invasive pectus excavatum repair in children: A randomized controlled non-inferiority study. J Clin Anesth. Published 8 September 2025. doi:10.
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