Pediatric anesthesia & critical care
Ultrasound-guided paravertebral block with liposomal bupivacaine vs. non-liposomal bupivacaine for postoperative pain control after the Nuss procedure in children: A randomized clinical trial
Primary result · Morphine equivalent consumptionResult — go to the resultMedian difference 23.1 mgAuthors' conclusion
Paravertebral bock with LB reduces opioid use (a ∼ 23 % reduction) and the incidence of rebound pain in children after the Nuss procedure compared to nLB group.
Study context
- Population
- Children aged 6–18 years scheduled for elective Nuss proceduresITT analysis
- Participants
- 109 children
- Comparison
- Ultrasound-guided paravertebral block with liposomal bupivacaine (LB) vs non-liposomal bupivacaine (nLB)
- LBn = 54
- nLBn = 55reference
- Primary endpoint
- Morphine equivalent consumption
- Follow-up
- First 72 h after surgery
Primary result
As reported in the abstract
72 h
Median difference
23.1 mg
P = 0.023
Secondary outcomes
%
| Outcome | LB | nLB | RR (95 % CI) | P value | |
|---|---|---|---|---|---|
| Rebound pain · 72 h | 13.0 | 29.1 | 0.46 (0.20 0.96) | P = 0.039 | |
| 0.20.5125Relative risk (log scale) |
| Outcome | Median difference (point) | P value |
|---|---|---|
| Subjective sleep quality · second and third nights after surgeryBetter in LB | −1 | P = 0.005 and P = 0.016 |
Safety
Events
| Outcome | LB | nLB |
|---|---|---|
| Adverse eventsEvents = severe adverse events | 0 | 0 |
- Adverse events — Severe adverse events
- 0
Adverse events
- Incidence of adverse events similar in both groups
Original publication
Ultrasound-guided paravertebral block with liposomal bupivacaine vs. non-liposomal bupivacaine for postoperative pain control after the Nuss procedure in children: A randomized clinical trial. J Clin Anesth. Published 5 August 2025. doi:10.
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