Ultrasound-guided Percutaneous Cryoneurolysis for the Treatment of Pain after Traumatic Rib Fracture: A Randomized, Active-controlled, Participant- and Observer-masked Study
Authors' conclusion
Ultrasound-guided percutaneous cryoneurolysis improves maximum inspired lung volume while concurrently decreasing pain and opioid consumption after traumatic rib fracture.
Study context
- Population
- Adults with one to six traumatic rib fractures
- Participants
- 11 vs 9
- Comparison
- Cryoneurolysis vs Peripheral nerve block
- Cryoneurolysisn = 11
- Peripheral nerve blockn = 9reference
- Primary endpoint
- Maximum inspired volume measured with an incentive spirometer
- Follow-up
- Day after the procedure
Methodological detailsactive-controlled, participant- and observer-masked
- Active-controlled
- Participant- and observer-masked
Primary result
As reported in the abstract
Maximum inspired volume
Mean difference
496
95% CI −428 to 1,420P = 0.269
unadjusted; t test
Adjusted mean difference
793 ml
95% CI 273–1,312P = 0.005
adjusted for covariates (e.g., baseline lung volume); analysis of covariance
Further findings
Total cumulative oxycodone equivalents · t test
P = 0.013
| Outcome | Cryoneurolysis | Peripheral nerve block | P value |
|---|---|---|---|
| Improvement from baseline in maximum inspired volumeT test · median, ml | 1,000 (IQR 1,000–1,375) | 300 (IQR 0–1,000) | P = 0.002 |
| Percent improvement over baseline in maximum inspired volumeT test · median | 100% (IQR 90%–188%) | 30% (IQR 0%–50%) | P = 0.003 |
Average daily pain scores · First month
- Generally lower in the cryoneurolysis group throughout the first month
Original publication
Ultrasound-guided Percutaneous Cryoneurolysis for the Treatment of Pain after Traumatic Rib Fracture: A Randomized, Active-controlled, Participant- and Observer-masked Study. Anesthesiology. Published 19 December 2024. doi:10.
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