Unique Pattern of Coagulopathy Among Patients With Severe Traumatic Brain Injury: A Principal Component Analysis of Hemorrhagic Shock Trials
Authors' conclusion
PC analysis demonstrated a unique pattern of coagulation biomarkers common to patients with severe TBI, irrespective of other injuries.
Study context
- Population
- Trauma patients randomized to placebo or standard of care in hemorrhagic shock trials, with complete international normalized ratio (INR), thromboelastography and AIS datacomplete data
- Participants
- 506 patients
- Exposure
- iTBI vs polytrauma (POLY) vs iTRUNK
- iTBIn = 51
- POLYn = 115
- iTRUNKn = 340
- Outcome
- Association of PC1 score with early transfusion (blood products within 24 hours)
- Follow-up
- 24 hours
Methodological detailsstratified principal component analysis, harmonized database of hemorrhagic shock trials
- Stratified principal component analysis
- Harmonized database of hemorrhagic shock trials
Main finding
As reported in the abstract
Odds ratio (95% CI)P value
iTBIPC1 included INR, AA, K time, and MA
3.57(1.50–8.45)
P = 0.004POLYPC1 included INR, AA, K time, and MA
2.29(1.11–4.75)
P = 0.026iTRUNKPC1 included INR, AA, and MA; protective
0.51(0.37–0.70)
P < 0.001Observational data: associations, not effects.
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Unique Pattern of Coagulopathy Among Patients With Severe Traumatic Brain Injury: A Principal Component Analysis of Hemorrhagic Shock Trials. Crit Care Med. Published 8 January 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →