Sepsis & infection

Use of landiolol in septic shock patients with new onset of atrial fibrillation: a European Delphi consensus

Crit CarePublished Delphi consensus

Methodological detailsmodified RAND/UCLA Delphi methodology, two Delphi rounds, multidisciplinary European panel, 55 statements across 9 thematic areas, 9-point Likert scale; consensus predefined as ≥ 80% agreement
  • Modified RAND/UCLA Delphi methodology
  • Two Delphi rounds
  • Multidisciplinary European panel
  • 55 statements across 9 thematic areas, 9-point Likert scale; consensus predefined as ≥ 80% agreement

Recommendations

As issued by the authors

  1. consensus

    Correct reversible triggers of AF

  2. consensus

    Haemodynamic assessment before HR control

  3. consensus

    Individualised cardioversion strategy

  4. consensus

    Landiolol for HR control in selected septic shock patients with new-onset atrial fibrillation (NOAF) (high β₁-selectivity, rapid titratability)

  5. consensus

    Start landiolol without bolus, at low doses gradually titrated, to an initial HR target below 110 bpm, guided by close haemodynamic and echocardiographic monitoring

  6. no consensus

    Optimal duration of landiolol therapy

  7. no consensus

    Use of landiolol in patients with severe ventricular dysfunction

Original publication

Use of landiolol in septic shock patients with new onset of atrial fibrillation: a European Delphi consensus. Crit Care. Published 7 August 2026. doi:10.1186/s13054-026-06200-9

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