Utilization of Intensive Care Interventions in Critically Ill Patients With Candidemia Versus Bacteremia: A Multicenter Retrospective Cohort Study
Authors' conclusion
Patients with significant ICU resource utilization are at increased risk for candidemia.
Study context
- Population
- ICU patients with a bloodstream infection, 8 hospitals in Houston, Texas, 2016–2023; validated in the MIMIC-IV cohortprimary cohort
- Participants
- 1,509 patients
- Exposure
- ICU-onset candidemia vs ICU-onset bacteremia
- Candidemian = 290
- Bacteremian = 1,219reference
- Outcome
- 30-day mortality
- Follow-up
- 30 days
Methodological detailsmulticentre, external validation cohort (MIMIC-IV)
- Multicentre
- External validation cohort (MIMIC-IV)
Main finding
As reported in the abstract
Candidemia vs BacteremiaEstimate (95% CI)
Primary cohort
unadjusted OR 1.62(1.25–2.09)
Primary cohort; adjusted for ICU interventions and baseline parameters
adjusted OR 1.21(0.92–1.60)
MIMIC-IV cohort
adjusted OR 1.48(1.003–2.17)
Observational data: associations, not effects.
Further findings
Invasive mechanical ventilation at time of culture
P < 0.001
Vasopressors at time of culture
P < 0.001
CRRT at time of culture
P = 0.006
Time in ICU to infection
P < 0.001
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Utilization of Intensive Care Interventions in Critically Ill Patients With Candidemia Versus Bacteremia: A Multicenter Retrospective Cohort Study. Crit Care Med. Published 11 November 2025. doi:10.
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