Validation of Adult Sepsis Event and Epidemiologic Analysis of Sepsis Prevalence and Mortality Using Adult Sepsis Event’s Electronic Health Records-Based Sequential Organ Failure Assessment Criteria: A Single-Center Study in South Korea*
Authors' conclusion
ASE demonstrated high sensitivity and a moderate PPV compared with the Sepsis-3 criteria in a Korean population. The prevalence of sepsis, as defined by ASE, was 5.4% per year and was similar to U.S. estimates. The prevalence of sepsis by ASE was eight times higher and exhibited less monthly variability compared with that based on the ICD-10 code.
Study context
- Population
- Adult inpatients or ED visitors (validation, November 5–11, 2019) and adult admissions January–December 2020, single centre in South Korea (2732 beds, 221 ICU beds)adult hospitalizations in 2020
- Participants
- 126,998 inpatients
- Exposure
- Adult Sepsis Event vs Sepsis-3 definition; Adult Sepsis Event (ASE) vs ICD-10 coding
- Outcome
- Diagnostic accuracy of ASE vs Sepsis-3; sepsis prevalence and mortality by ASE
Methodological detailssingle-centre, diagnostic validation phase, epidemiologic analysis phase
- Single-centre
- Diagnostic validation phase
- Epidemiologic analysis phase
Main finding
As reported in the abstract
Diagnostic accuracy of ASE vs Sepsis-3
| Group | Sensitivity | Specificity | PPV | NPV |
|---|---|---|---|---|
| ASE | 91.6% | 98.3% | 57.4% | 99.8% |
ASE
Sensitivity91.6%
Specificity98.3%
PPV57.4%
NPV99.8%
Observational data: associations, not effects.
Further findings
Hospital mortality
| Outcome | ASE | ICD-10 | P value |
|---|---|---|---|
| Sepsis prevalence, 2020 | 5.4% per year | 0.7% per year | |
| Monthly variation (coefficient of variation) of sepsis prevalenceMiller test · CV | 0.051 | 0.163 | P < 0.001 |
| Monthly variation (coefficient of variation) of hospital mortalityCV | 0.087 | 0.261 | P = 0.001 |
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Validation of Adult Sepsis Event and Epidemiologic Analysis of Sepsis Prevalence and Mortality Using Adult Sepsis Event’s Electronic Health Records-Based Sequential Organ Failure Assessment Criteria: A Single-Center Study in South Korea*. Crit Care Med. Published 26 March 2024. doi:10.
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