Variation in coagulation factor activity levels cause discrepancies between activated partial thromboplastin time and anti-Xa activity for heparin monitoring: a retrospective observational study
Authors' conclusion
Discrepancies between APTT and anti-Xa activity were frequently observed, influenced by changes in coagulation factors activity levels.
Study context
- Population
- Critically ill patients receiving continuous IV unfractionated heparin (UFH)271 paired samples
- Participants
- 99 patients
- Exposure
- Activated partial thromboplastin time (APTT) vs anti-Xa activity for UFH monitoring
- Outcome
- Concordance between APTT and anti-Xa activity
Main finding
As reported in the abstract
Overall concordance rate
45%
Discrepancy rate
55%
Observational data: associations, not effects.
Further findings
- Lower group frequently showed apparent heparin overdoses
- Coagulation factor activities higher in lower group and lower in upper group vs concordant group
- Factor VIII activity higher in lower group vs upper and concordant groups
Original publication
Variation in coagulation factor activity levels cause discrepancies between activated partial thromboplastin time and anti-Xa activity for heparin monitoring: a retrospective observational study. J Intensive Care. Published 16 November 2023. doi:10.
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