Perioperative medicine & outcomes
Ventricular septum curvature ratio: a novel imaging marker to predict clinical deterioration in normotensive acute pulmonary embolism
Authors' conclusion
The VS curvature ratio, derived from CTPA images, is a promising image marker for predicting deterioration in normotensive acute PE patients.
Study context
- Population
- Normotensive patients with acute pulmonary embolism (PE), five centres in China, January 2021–June 2024272 (8.2%) deteriorated
- Participants
- 3,310 patients
- Exposure
- Ventricular septum (VS) curvature ratio categories (computed tomography pulmonary angiography (CTPA)) vs ratio < 1.60
- Outcome
- Clinical deterioration event
- Follow-up
- Within 30 days after admission
Methodological detailsmulticentre, five centres in China
- Multicentre
- Five centres in China
Main finding
As reported in the abstract
Clinical deterioration by VS curvature ratio category · 30 days
Odds ratio
22.94
P < 0.05
≥ 1.90
Odds ratio
22.95
P < 0.05
VS straight & bowing to the left ventricle (LV)
Observational data: associations, not effects.
Further findings
Discrimination of VS curvature ratio for deterioration
- AUC, three local centres
- 0.83
- AUC, two non-local centres (280 patients)
- 0.84
Original publication
Ventricular septum curvature ratio: a novel imaging marker to predict clinical deterioration in normotensive acute pulmonary embolism. Crit Care. Published 31 October 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →