Sepsis & infection

[18F]FDG PET/CT identifies infectious and inflammatory foci in persistent critical illness

Ann Intensive CarePublished Retrospective cohort study

Authors' conclusion

[18F]FDG PET/CT detected a considerable number of (new) infectious and inflammatory foci in patients with persistent critical illness, often followed by a change in therapy.

Study context

Population
ICU patients with persistent critical illness with [18F]FDG PET/CT ≥10 days after ICU admission, 2017–2024
Participants
47 patients · 2 university medical centres
Outcome
Ability of [18F]FDG PET/CT to identify infectious and inflammatory foci, and its impact on subsequent therapy management
Methodological detailsdual centre
  • Dual centre

Main finding

As reported in the abstract

Potential infectious or inflammatory focus detected

Potential infectious or inflammatory focus detected

43 patients

91%

Previously unknown foci

34

72%

Therapy change within 48 h after PET/CT

26

55%

Observational data: associations, not effects.

Further findings

Interval between admission and PET/CT

Median interval, days (IQR 14-28)
21

Diagnostic procedures performed before PET/CT

Median number of procedures (IQR 6.0-8.0)
7
  • PET/CT used late in diagnostic work-up

Original publication

[18F]FDG PET/CT identifies infectious and inflammatory foci in persistent critical illness. Ann Intensive Care. Published 20 February 2025. doi:10.1186/s13613-025-01444-0

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