[18F]FDG PET/CT identifies infectious and inflammatory foci in persistent critical illness
Authors' conclusion
[18F]FDG PET/CT detected a considerable number of (new) infectious and inflammatory foci in patients with persistent critical illness, often followed by a change in therapy.
Study context
- Population
- ICU patients with persistent critical illness with [18F]FDG PET/CT ≥10 days after ICU admission, 2017–2024
- Participants
- 47 patients · 2 university medical centres
- Outcome
- Ability of [18F]FDG PET/CT to identify infectious and inflammatory foci, and its impact on subsequent therapy management
Methodological detailsdual centre
- Dual centre
Main finding
As reported in the abstract
Potential infectious or inflammatory focus detected
Potential infectious or inflammatory focus detected
43 patients
91%
Previously unknown foci
34
72%
Therapy change within 48 h after PET/CT
26
55%
Observational data: associations, not effects.
Further findings
Interval between admission and PET/CT
- Median interval, days (IQR 14-28)
- 21
Diagnostic procedures performed before PET/CT
- Median number of procedures (IQR 6.0-8.0)
- 7
- PET/CT used late in diagnostic work-up
Original publication
[18F]FDG PET/CT identifies infectious and inflammatory foci in persistent critical illness. Ann Intensive Care. Published 20 February 2025. doi:10. 1186/ s13613-025-01444-0
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