A 1-Hour Resuscitation Bundle for Prehospital Management of Septic Shock
Primary resultResult — go to the resultRelative risk 0.81 95% CI 0.61–1.08Authors' conclusion
The prehospital initiation of a 1-hour resuscitation bundle did not reduce 28-day all-cause mortality in adults with septic shock.
Study context
- Population
- Adults with suspected septic shock managed by a prehospital mobile ICU team, France381 analysed
- Participants
- 398 adults
- Comparison
- Prehospital 1-hour resuscitation bundle vs usual care
- 1-hour bundlen = 103
- Usual caren = 278reference
- Primary endpoint
- All-cause mortality
- Follow-up
- 28 days
Methodological detailsmulticentre, open-label, cluster-randomised
- Multicentre
- Open-label
- Cluster-randomised
Primary result
As reported in the abstract
Relative risk
0.81
95% CI 0.61–1.08
P = 0.16
Events by treatment group
1-hour bundle vs Usual care
RR 0.81 (95% CI 0.61–1.08); P = 0.16
Secondary outcomes
ICU, hospital discharge and 90-day mortality; time alive free of vasopressors, invasive mechanical ventilation, RRT; ICU and hospital LOS
- Similar between groups
Original publication
A 1-Hour Resuscitation Bundle for Prehospital Management of Septic Shock. Crit Care Med. Published 10 August 2026. doi:10.
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