Impact of prehospital antibiotic therapy differs depending on septic shock origin
Main finding · 30-day mortalityResult — go to the resultRelative risk 0.64 95% CI 0.41–0.97Authors' conclusion
The prehospital antibiotics administration is associated with a reduced risk of 30-day mortality among patients suffering from septic shock cared for by a prehospital MICU. The prehospital antibiotic treatment effect differs according to septic shock origin.
Study context
- Population
- Septic shock patients (Sepsis-2) admitted to ICU after prehospital care by a mobile ICU (mobile intensive care unit (MICU)), France, May 2016 to December 2021analysed
- Participants
- 530 patients
- Exposure
- Prehospital antibiotics vs No prehospital antibiotics
- Prehospital antibioticsn = 132
- Outcome
- 30-day mortality
- Follow-up
- 30 days
Methodological detailsnationwide, target trial emulation, inverse probability of treatment weighting
- Nationwide
- Target trial emulation
- Inverse probability of treatment weighting
Main finding
As reported in the abstract
Relative risk
0.64
95% CI 0.41–0.97
Prehospital antibiotics vs No prehospital antibiotics
RR 0.64 (95% CI 0.41–0.97)
Observational data: associations, not effects.
Further findings
| Outcome | RRa (CI) |
|---|---|
| 30-day mortality by presumed septic shock origin (subgroup) · 30 daysPrehospital antibiotics vs No prehospital antibiotics · pulmonary origin · weighted logistic regression model | 0.80 (0.86–0.93) |
| 30-day mortality by presumed septic shock origin (subgroup) · 30 daysPrehospital antibiotics vs No prehospital antibiotics · urinary origin · weighted logistic regression model | 0.89 (0.80–0.98) |
| 30-day mortality by presumed septic shock origin (subgroup) · 30 daysPrehospital antibiotics vs No prehospital antibiotics · unknown origin · weighted logistic regression model | 0.94 (0.86–0.99) |
Original publication
Impact of prehospital antibiotic therapy differs depending on septic shock origin. J Intensive Care. Published 2 March 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →