Perioperative medicine & outcomes
A bundle to prevent postinduction hypotension in high-risk noncardiac surgery patients: the ZERO-HYPOTENSION single-arm interventional proof-of-concept study
Authors' conclusion
We observed minimal postinduction hypotension in high-risk noncardiac surgery patients treated with a hypotension prevention bundle.
Study context
- Population
- High-risk noncardiac surgery patients
- Participants
- 107 patients
- Outcome
- AUC65: area under a MAP of 65 mm Hg on the plot of MAP over time
- Follow-up
- First 15 min after induction of GA
Main finding
As reported in the abstract
AUC65 (area under MAP 65 mm Hg, first 15 min after induction of GA) · first 15 min after induction
Median AUC65 (25th, 75th percentile; min–max: 0.0, 4.1; 0.0-40.6 mm Hg min)
0.1 mm Hg . min
Observational data: associations, not effects.
Further findings
At least one mean arterial pressure (MAP) reading <65 mm Hg
- Patients with ≥1 MAP reading <65 mm Hg, of 107
- 55 (51%)
MAP <65 mm Hg for ≥1 continuous minute
- Patients with MAP <65 mm Hg for ≥1 continuous minute
- 16/107 (15%)
Time with MAP <65 mm Hg
- Median time with MAP <65 mm Hg (25th, 75th percentile; min–max: 0.0, 0.8; 0.0-5.2 min)
- 0.2 min
Original publication
A bundle to prevent postinduction hypotension in high-risk noncardiac surgery patients: the ZERO-HYPOTENSION single-arm interventional proof-of-concept study. BJA Open. Published 11 April 2025. doi:10.
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