A comprehensive echocardiographic analysis during simulated hypovolaemia: An observational study
Authors' conclusion
In this study, simulated central hypovolaemia using LBNP did not induce consistent changes in MAP and HR. SVI decreased and was associated with deteriorated right- and left-ventricular function, observed with echocardiography. The decreased filling status was characterised by decreased LA ESV.
Study context
- Population
- Healthy male volunteers undergoing simulated central hypovolaemia (lower body negative pressure (LBNP)), Berlin, Germany
- Participants
- 30 healthy male volunteers
- Exposure
- Graded LBNP stages vs baseline
- Outcome
- Systolic and diastolic myocardial performance markers and cardiac volumes on TTE vs baseline
Methodological detailslaboratory trial, graded lower body negative pressure, TTE performed at every stage by a certified examiner
- Laboratory trial
- Graded lower body negative pressure
- TTE performed at every stage by a certified examiner
Main finding
As reported in the abstract
- Stroke volume index (SVI) decreased progressively at all stages; Mean arterial pressure (MAP) and HR did not consistently change
- Left ventricular (LV) ejection fraction decreased at −30 and −45 mmHg
- LV GLS, tricuspid annular plain systolic excursion (TAPSE), RV S' and LA ESV decreased vs baseline at all stages
Observational data: associations, not effects.
Original publication
A comprehensive echocardiographic analysis during simulated hypovolaemia: An observational study. Eur J Anaesthesiol. Published 1 June 2023. doi:10.
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