A Double-Blinded Randomized Trial Comparing Dexamethasone to Ondansetron as the First-Line Antiemetic After Cesarean Delivery
Authors' conclusion
We found no differences in the number of medications used to treat pain, nausea, or pruritus in the first 24 hours after cesarean delivery between women who received either ondansetron or dexamethasone.
Study context
- Population
- Women undergoing cesarean delivery under spinal anesthesia with morphine 150 µg and an enhanced recovery after cesarean protocol95 completed
- Participants
- 100 women
- Comparison
- Dexamethasone 8 mg vs ondansetron 4 mg as first-line antiemetic
- Primary endpoint
- Total number of medications for treatment of any nausea and vomiting, pain, or pruritus
- Follow-up
- First 24 hours
Methodological detailsprospective, double-blinded
- Prospective
- Double-blinded
Primary result
As reported in the abstract
Number of postoperative medications (per patient per 24 hours) · 24 hours
P = 0.337
Further findings
Supplemental pain medication use and pain scores · 24 hours
- Differences not statistically significant
Nausea and pruritus scores · 24 hours
- Differences not statistically significant
Original publication
A Double-Blinded Randomized Trial Comparing Dexamethasone to Ondansetron as the First-Line Antiemetic After Cesarean Delivery. Anesth Analg. Published 10 September 2026. doi:10.
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