Perioperative medicine & outcomes
A dynamic elastance-based protocol to guide intra-operative fluid management in major abdominal surgery: A randomised clinical trial
Authors' conclusion
A protocol including Ea dyn to treat hypotension did not reduce lactate after major abdominal surgery, but it was associated with a significant reduction in fluid balance and increase in oxygen consumption.
Study context
- Population
- Patients scheduled for cephalic duodenopancreatectomy at a high-volume tertiary centre for pancreatic surgeryeligible of 58 scheduled
- Participants
- 46 patients
- Comparison
- Ea dyn vs Control
- Primary endpoint
- Lactate value
- Follow-up
- 1 h after extubation (T3)
Methodological detailsopen-label, single-centre
- Open-label
- Single-centre
Primary result
As reported in the abstract
Lactate at T3 · T3
- Lactate levels at T3 similar between the Control and Ea dyn groups
Secondary outcomes
Median, %
| Outcome | Ea dyn | Control | P value |
|---|---|---|---|
| Lactate percentage change from T2 to T3Significant percentage decrease in Ea dyn | −24.5 (IQR −30–-14) | 0 (IQR −24–7.6) | P = 0.004 |
Oxygen consumption · T3
- Higher oxygen consumption in the Ea dyn group at T3
Fluid balance · T3
- Lower fluid balance in the Ea dyn group at T3 (median [IQR])
- 2700 [2100 to 3800] vs. 2200 [1060 to 3000] ml, P = 0.020
Vasopressor use
- More vasopressors in the Ea dyn group
Postoperative complications and hospital stay
- No significant differences
Original publication
A dynamic elastance-based protocol to guide intra-operative fluid management in major abdominal surgery: A randomised clinical trial. Eur J Anaesthesiol. Published 11 March 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →