Perioperative medicine & outcomes
Intra‐operative hypotension threshold models and subdistribution hazard of postoperative pneumonia in patients having non‐cardiac surgery
Authors' conclusion
Intra-operative hypotension was associated with postoperative pneumonia when defined as a relative reduction from baseline mean arterial pressure, whereas conventional absolute thresholds were less informative. These findings suggest that maintaining intra-operative blood pressure close to baseline may be more relevant to pulmonary risk than relying on fixed absolute thresholds alone.
Study context
- Population
- adults undergoing non-cardiac surgery under general anaesthesia at three Chinese hospitalsadults undergoing non-cardiac surgery under general anaesthesia at three Chinese hospitals
- Participants
- 151,036 adults
- Exposure
- Absolute thresholds vs Relative reductions
- Outcome
- Postoperative pneumonia
- Follow-up
- Within 30 days
Main finding
As reported in the abstract
Subdistribution hazard ratio (95% CI)P value
Number of intra-operative hypotension episodes at a 20% reduction from baseline
1.079(1.050–1.109)
P < 0.001Presence of intra-operative hypotension at a 20% reduction from baseline
1.108(1.068–1.149)
P < 0.001- Postoperative pneumonia, all patients
- 3486 (2.3%)
Observational data: associations, not effects.
Further findings
Duration-related metrics
- Duration-related metrics were generally less consistent than depth- or recurrence-related metrics
Dose-response analyses
- Risk increased rapidly at low exposure levels and then plateaued across relative thresholds of 20-40%
Original publication
Intra‐operative hypotension threshold models and subdistribution hazard of postoperative pneumonia in patients having non‐cardiac surgery. Anaesthesia. Published 2 October 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →