Perioperative medicine & outcomes
Association between Intraoperative Hypotension and Postoperative Delirium: A Retrospective Cohort Analysis
Authors' conclusion
To the extent of hypotension observed in our cohort, our results suggest that intraoperative hypotension is not associated with postoperative delirium in elderly patients having elective noncardiac surgery.
Study context
- Population
- Patients older than 70 yr having elective noncardiac surgery, single tertiary academic centre, 2020–2021
- Participants
- 2,352 participants
- Exposure
- Quartiles of intraoperative area under mean arterial pressure (MAP) 65 mmHg threshold
- Outcome
- Postoperative delirium (composite:
- Positive 4 A's test during initial 2 postoperative days
- Chart-based Delirium Identification Instrument)
Methodological detailssingle-centre, multivariable logistic regression
- Single-centre
- Multivariable logistic regression
Main finding
As reported in the abstract
Postoperative delirium
Each group vs first quartileAdjusted odds ratio (95% CI)P value
Second quartile
0.94(0.64–1.36)
P = 0.73Third quartile
0.95(0.66–1.36)
P = 0.78Fourth quartile
0.95(0.65–1.36)
P = 0.78- Overall incidence of postoperative delirium
- 14% (327 of 2,352)
- Median [IQR] area under MAP <65 mmHg (mmHg · min)
- 28 [0, 103]
Observational data: associations, not effects.
Further findings
Sensitivity and subgroup analyses
- Intraoperative hypotension not associated with postoperative delirium in any sensitivity or subgroup analysis
Original publication
Association between Intraoperative Hypotension and Postoperative Delirium: A Retrospective Cohort Analysis. Anesthesiology. Published 12 July 2024. doi:10.
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