Perioperative medicine & outcomes
Intraoperative hypotension during liver transplantation and postoperative outcomes: Retrospective cohort study
Authors' conclusion
Our results did not show the association between IOH and investigated outcomes.
Study context
- Population
- Patients undergoing liver transplant at a single institution, January 2005–February 2022
- Participants
- 1,576 patients
- Exposure
- Higher vs lower intraoperative hypotension (IOH) exposure
- Outcome
- Severity of AKI (odds of more severe AKI, proportional odds model)
Methodological detailssingle institution
- Single institution
Main finding
As reported in the abstract
Odds ratio (95% CI)P value
50-mmHg·min increase in AUT of MAP <55 mmHg
1.02(0.997–1.04)
P = 0.09215-min increase in time spent under MAP <55 mmHg
1.03(0.98–1.07)
P = 0.271 mmHg increase in TWA of MAP <55 mmHg
1.24(0.98–1.57)
P = 0.068- Acute kidney injury (AKI) after liver transplant
- 1160 (74%)
- Mild AKI
- 780 (49%)
- Moderate AKI
- 248(16%)
- Severe AKI
- 132 (8.4%)
Observational data: associations, not effects.
Further findings
- Associations between IOH and incidence of MACE or early allograft dysfunction (EAD) not significant
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Intraoperative hypotension during liver transplantation and postoperative outcomes: Retrospective cohort study. J Clin Anesth. Published 9 May 2024. doi:10.
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