Perioperative medicine & outcomes
Association of Intraoperative Hypotension with Postoperative Nausea and Vomiting in Laparoscopic Gastrointestinal Surgery: A Secondary Analysis of a Randomized Trial
Authors' conclusion
Intraoperative hypotension was not associated with PONV in patients at high risk of PONV who underwent laparoscopic gastrointestinal surgery.
Study context
- Population
- Adults at high risk for postoperative nausea and vomiting (PONV) undergoing laparoscopic gastrointestinal surgery96.4% women
- Participants
- 1,093 adults
- Comparison
- Second and third vs first tertile of time-weighted average mean arterial pressure (TWA-MAP) <65 mmHg
- Primary endpoint
- PONV
- Follow-up
- 0 to 24 h after surgery
Methodological detailsrestricted cubic splines, multiple logistic regression, sensitivity analyses
- Restricted cubic splines
- Multiple logistic regression
- Sensitivity analyses
Primary result
As reported in the abstract
0 to 24 h
Each group vs first tertileAdjusted odds ratio (95% CI)P value
Second tertile
0.92(0.67–1.24)
P = 0.569Third tertile
0.95(0.70–1.30)
P = 0.755- Overall PONV incidence
- 40.4%
Secondary outcomes
| Outcome | aOR (95% CI) | P value | |
|---|---|---|---|
| PONV · 25 to 120 hSecond tertile vs First tertile | 1.05 (0.77–1.42) | P = 0.772 | |
| PONV · 25 to 120 hThird tertile vs First tertile | 0.86 (0.63–1.18) | P = 0.360 | |
| 0.512Adjusted odds ratio (log scale) |
- PONV — Overall PONV incidence
- 42.9%
Sensitivity analyses (MAP thresholds 70, 60, 55 mmHg; AUC, duration)
- Intraoperative hypotension not associated with PONV in any sensitivity analysis
Original publication
Association of Intraoperative Hypotension with Postoperative Nausea and Vomiting in Laparoscopic Gastrointestinal Surgery: A Secondary Analysis of a Randomized Trial. Anesthesiology. Published 2 June 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →