Respiratory failure & ventilation

A machine learning algorithm for detecting abnormal patterns in continuous capnography and pulse oximetry monitoring

J Clin Monit ComputPublished Secondary analysis of the PRODIGY observational trial

Authors' conclusion

Our algorithm reliably distinguishes normal from abnormal waveforms.

Study context

Population
Patients receiving parenteral opioids with continuous capnography and pulse oximetry monitoring on the general care floorsequences (2,944 abnormal)
Participants
7,858 patients
Comparison
Five machine learning (ML) models classifying combined capnography and pulse oximetry waveforms as normal or abnormal
Primary endpoint
Fβ score (β = 2) for classifying waveforms as normal or abnormal
Methodological detailsmachine learning model development study, prospective, 80% training / 20% test split, Abnormal segments: 60s before and 30s after an abnormal pattern; normal segments: 90s continuous monitoring, randomly sampled
  • Machine learning model development study
  • Prospective
  • 80% training / 20% test split
  • Abnormal segments: 60s before and 30s after an abnormal pattern; normal segments: 90s continuous monitoring, randomly sampled

Primary result

As reported in the abstract

Classification performance, test sequences
GroupFβ score (β = 2)RecallPrecision
XGBoost0.940.980.83

XGBoost

Fβ score (β = 2)0.94
Recall0.98
Precision0.83

Further findings

Inter-rater agreement of nine experts on abnormal segments

High inter-rater agreement
> 87%

Original publication

A machine learning algorithm for detecting abnormal patterns in continuous capnography and pulse oximetry monitoring. J Clin Monit Comput. Published 15 April 2024. doi:10.1007/s10877-024-01155-0

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