A multicentre prospective registry of one thousand sepsis patients admitted in Indian ICUs: (SEPSIS INDIA) study
Authors' conclusion
The mortality of sepsis cohort was higher (36.3%) but septic shock mortality (50.8%) was comparable to Western reports.
Study context
- Population
- Adult ICU patients with sepsis or septic shock (Sepsis 3 criteria) in 19 ICUs in India, August 2022-July 2023; COVID-19 excluded
- Participants
- 1,172 patients · 19 ICUs
- Exposure
- Without shock vs With shock
- Without shockn = 672
- With shockn = 500
- Outcome
- Hospital mortality
Main finding
As reported in the abstract
- Hospital mortality, entire cohort
- 36.3%
Observational data: associations, not effects.
Further findings
Microbiology
- Gram negative organisms among culture positive results
- 65%
- Carbapenem-resistance in gram negative blood culture isolates
- 50%
- Klebsiella spp
- 25%
- Escherechia coli
- 24%
- Acinetobacter Spp
- 11%
- Tropical infections (Dengue, Malaria, Typhus)
- 2.2%
- Tropical infections n = 32
ICU and hospital LOS
- Average ICU LOS
- 8.64
- Average hospital LOS
- 11.9
- Unit not printed
Predictors of mortality (multivariate analysis)
- Adequate source control, correct choice of empiric antibiotic and IV thiamine were protective
Original publication
A multicentre prospective registry of one thousand sepsis patients admitted in Indian ICUs: (SEPSIS INDIA) study. Crit Care. Published 19 November 2024. doi:10.
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