Respiratory failure & ventilation
A novel method for assessment of airway opening pressure without the need for low-flow insufflation
Authors' conclusion
Determination of Pcond during constant-flow assist control ventilation may permit to easily and safely detect and measure AOP.
Study context
- Population
- Mechanically ventilated patients under volume assist control ventilation45 in tolerance comparison
- Participants
- 213 participants
- Comparison
- Pcond vs Standard low-flow
- Outcome
- AOP detection
Methodological detailsbench models (lung simulator, cadavers), Bench assessments validated the Pcond method proof-of-concept
- Bench models (lung simulator, cadavers)
- Bench assessments validated the Pcond method proof-of-concept
Performance
As reported in the abstract
| Test or model | Sensitivity | Specificity |
|---|---|---|
| Pcond | 93% | 91% |
Pcond
Sensitivity93%
Specificity91%
Further findings
| Outcome | R | P value |
|---|---|---|
| Correlation of AOP by Pcond and standard low-flow methods | 0.84 | P < 0.001 |
Safety
| Outcome | P value |
|---|---|
| Changes in SpO2Significantly lower during Pcond | P < 0.001 |
- Changes in SpO2: 45 patients
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
A novel method for assessment of airway opening pressure without the need for low-flow insufflation. Crit Care. Published 7 July 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →