Respiratory failure & ventilation
Ventilator settings for fiberoptic bronchoscopy during mechanical ventilation: a randomized adjudicator-blinded controlled trial VentSetFib
Authors' conclusion
A bronchoscopy-optimized ventilation strategy substantially reduces pressure-alarm-limited ventilation events and enables the delivery of adequate ventilatory support during fiberoptic bronchoscopy.
Study context
- Population
- Intubated adults undergoing fiberoptic bronchoscopy during mechanical ventilation
- Participants
- 23 vs 23
- Comparison
- Optimized vs Conventional
- Optimizedn = 23
- Conventionaln = 23reference
- Primary endpoint
- Composite of serious adverse events requiring premature termination (inability to deliver ventilatory support, significant arterial desaturation, or hemodynamic instability), adjudicated by blinded experts
Methodological detailssingle-centre, adjudicator-blinded, 1:1 allocation
- Single-centre
- Adjudicator-blinded
- 1:1 allocation
Primary result
As reported in the abstract
Risk difference
−91.3%
P < 0.001
Optimized
Relative risk
0.05
P < 0.001
Optimized
Further findings
Delivered tidal volume
P < 0.001
Minute ventilation
P < 0.001
- Delivered tidal volume: events driven by ventilatory failure due to pressure-alarm limitation
Crossover patients switched to optimized settings
- Reduced peak airway pressure and restored adequate ventilation (19 crossover patients)
Safety
Respiratory and circulatory events
Respiratory and circulatory events
- Rare and similar between groups (each 1/23 [4%])
Original publication
Ventilator settings for fiberoptic bronchoscopy during mechanical ventilation: a randomized adjudicator-blinded controlled trial VentSetFib. Crit Care. Published 27 January 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →