Respiratory failure & ventilation
Evaluation of decision support to wean patients from mechanical ventilation in intensive care: a prospective study reporting clinical and physiological outcomes
- terminated early
- Terminated early
Authors' conclusion
It was terminated early, with no significant difference shown in duration of mechanical ventilation, the primary outcome. Application of advice indicated potential for fewer adverse events and improved physiological status.
Study context
- Population
- Intubated adults mechanically ventilated >24 h in 5 UK ICUs
- Participants
- 112 participants
- Comparison
- Intervention vs Usual care
- Interventionn = 54
- Usual caren = 58reference
- Primary endpoint
- Duration of mechanical ventilation
Methodological detailsmulticentre, prospective
- Multicentre
- Prospective
Primary result
As reported in the abstract
- Intervention vs Usual care: P = 0.773
- Study terminated early and underpowered
Secondary outcomes
| Outcome | P value |
|---|---|
| PEEPLower in Intervention | P = 0.030 |
| Tidal volumeLower in Intervention | P = 0.042 |
| Peak inspiratory pressureReduced, at the border of statistical significance | P = 0.104 |
| Pressure supportReduced, at the border of statistical significance | P = 0.093 |
Prolonged intubation and survival
- No significant differences
Time in ventilator mode and other therapy
- No differences
Application of decision support advice
- Advice applied at the bedside, average % of occasions
- 88%
- Significantly increased number of changes only in inspired oxygen fraction
Time spent outside physiological limits
- No significant differences
Safety
| Outcome | P value |
|---|---|
| Adverse eventsLower rates in Intervention | P = 0.016 |
| Hypoxaemic eventsFewer in Intervention | P = 0.008 |
Original publication
Evaluation of decision support to wean patients from mechanical ventilation in intensive care: a prospective study reporting clinical and physiological outcomes. J Clin Monit Comput. Published 9 November 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →