Respiratory failure & ventilation
Impacts of three inspiratory muscle training programs on inspiratory muscles strength and endurance among intubated and mechanically ventilated patients with difficult weaning: a multicentre randomised controlled trial
Authors' conclusion
Among difficult-to-wean patients receiving invasive MV, no statistically difference was observed in strength and endurance progression across three different IMT programs.
Study context
- Population
- Intubated, mechanically ventilated difficult-to-wean patients
- Participants
- 92 participants
- Comparison
- Mixed intensity (MI) vs low intensity (LI) vs high intensity (HI)
- Primary endpoint
- Maximal inspiratory pressure (MIP) increase
Methodological detailsmulticentre, parallel
- Multicentre
- Parallel
Primary result
As reported in the abstract
MIP increase
Mean adjusted difference
6.59
97.5% CI - 14.36; 1.18P = 0.056
MI vs LI
Mean adjusted difference
- 3.52
97.5% CI - 11.57; 4.53P = 0.321
MI vs HI
MI
10.8
mean · SD 11.9 · cmH2O
LI
4.5
mean · SD 14.8 · cmH2O
HI
6.7
mean · SD 14.5 · cmH2O
Secondary outcomes
| Outcome | MI | LI | HI |
|---|---|---|---|
| Weaning success (2 days ventilator-free after extubation) | 83.7% (95% CI 69.3–93.2) | 73.9% (95% CI 51.6–89.8) | 82.6% (95% CI 61.2–95.0) |
Peak pressure (Ppk) increase (endurance marker)
- No significant differences among the three groups
Mechanical ventilation (MV) duration, ICU LOS, reintubation rate
- Similar values across groups
Safety
Adverse events possibly related to the study
- Adverse events over 629 inspiratory muscle training (IMT) sessions
- 6
- Spontaneously reversible bradycardia in LI
- 4
Original publication
Impacts of three inspiratory muscle training programs on inspiratory muscles strength and endurance among intubated and mechanically ventilated patients with difficult weaning: a multicentre randomised controlled trial. J Intensive Care. Published 25 July 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →