A prospective observational study of the efficacy of ketamine for rescue analgesia in the postanesthesia recovery unit
Authors' conclusion
Administration of low-dose bolus ketamine in the PACU for severe opioid-resistant pain was associated with a significant improvement in analgesia in this observational study.
Study context
- Population
- Adult noncardiac surgery patients with significant opioid-resistant postoperative pain in the postanesthesia care unit (PACU)convenience sample
- Participants
- 100 patients
- Outcome
- Resting numerical rating scale (NRS) pain score reduction and opioid use from ketamine bolus to 30 min after final bolus
- Follow-up
- 30 min after final ketamine bolus
Methodological detailsconvenience sample
- Convenience sample
Main finding
As reported in the abstract
Resting NRS pain score reduction · 30 min after iv ketamine
Ketamine
2.7
mean · SD 1.8
Observational data: associations, not effects.
Secondary outcomes
Response in patients with previous opioid use or chronic pain (subgroup)
- Not more responsive to low-dose bolus ketamine
Safety
- No ketamine-related adverse effects in any of the study patients
Original publication
A prospective observational study of the efficacy of ketamine for rescue analgesia in the postanesthesia recovery unit. Can J Anaesth. Published 27 February 2023. doi:10.
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