The Effect of Intravenous Lidocaine, Ketamine, and Lidocaine–Ketamine Combination in Colorectal Cancer Surgery: A Randomized Controlled Trial
Authors' conclusion
Our study results do not support the use of an intraoperative combination of lidocaine and ketamine in patients undergoing open surgery for CRC.
Study context
- Population
- Patients undergoing elective open colorectal resection for colorectal cancer (CRC)
- Participants
- 82 patients
- Comparison
- IV lidocaine and/or ketamine vs placebo during open colorectal resection
- Primary endpoint
- Serum WBC count, IL-6, IL-8 and CRP (Bonferroni-adjusted significance level .00625)
- Follow-up
- 12 and 36 hours after surgery
Methodological details2 × 2 factorial, placebo-controlled
- 2 × 2 factorial
- Placebo-controlled
Primary result
As reported in the abstract
Inflammatory markers (WBC, IL-6, IL-8, CRP)
- Multiplicative interaction, white blood cell (WBC) count, 12 and 36 h
- P = .870 and P = .393
- Multiplicative interaction, interleukins (IL-6), 12 and 36 h
- P = .892 and P = .343
- Multiplicative interaction, IL-8, 12 and 36 h
- P = .999 and P = .996
- Multiplicative interaction, C-reactive protein (CRP), 12 and 36 h
- P = .014 and P = .445
Secondary outcomes
Intraoperative opioid consumption
- Lidocaine and ketamine, together or alone, significantly reduced intraoperative opioid consumption vs placebo
Visual analog scale (VAS) pain scores
- Improved with lidocaine and ketamine together or ketamine alone, not with lidocaine alone
Time to first bowel movement (gut motility)
- Neither intervention significantly influenced gut motility
Original publication
The Effect of Intravenous Lidocaine, Ketamine, and Lidocaine–Ketamine Combination in Colorectal Cancer Surgery: A Randomized Controlled Trial. Anesth Analg. Published 24 May 2023. doi:10.
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