Analgesic Efficacy of Repeated Daily Injections Versus Continuous Adductor Canal Block After Total Knee Arthroplasty: An Open-Label, Randomized Clinical Trial
Authors' conclusion
This study was unable to determine whether repeated daily injections or continuous adductor canal block provided superior analgesia in terms of the average pain score during the first 2 days after total knee arthroplasty.
Study context
- Population
- Patients undergoing total knee arthroplasty under spinal anesthesia, with perioperative multimodal analgesia
- Participants
- 76 patients
- Comparison
- Repeated daily injections vs continuous adductor canal block
- Repeated injectionn = 39
- Continuousn = 37reference
- Primary endpoint
- Time-weighted average NRS pain score at rest
- Follow-up
- End of surgery to 14:00 on POD2
Methodological detailsopen-label
- Open-label
Primary result
As reported in the abstract
Mean difference
0.09
95% CI −0.81 to 0.99
P = 0.842
By group
Repeated injection
2.9
± 1.9
Continuous
3.1
± 2.1
Repeated injection vs Continuous
mean difference 0.09 (95% CI −0.81 to 0.99); P = 0.842
Further findings
Pain at rest and during movement over time (generalized estimating equations)
- Repeated daily injections did not reduce pain at rest or during movement after adjusting for time
Safety
Cumulative nerve block catheter dislocation (ultrasonography), Continuous
- POD1
- 48.6% (18/37)
- POD2
- 62.2% (23/37)
Original publication
Analgesic Efficacy of Repeated Daily Injections Versus Continuous Adductor Canal Block After Total Knee Arthroplasty: An Open-Label, Randomized Clinical Trial. Anesth Analg. Published 18 February 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →