A randomised controlled trial of the non‐inferiority of erector spinae plane block vs. thoracic paravertebral block for laparoscopic nephro‐ureterectomy
Authors' conclusion
Erector spinae block analgesia was not inferior to paravertebral block analgesia after laparoscopic nephroureterectomy.
Study context
- Population
- Adults scheduled for laparoscopic nephroureterectomy
- Participants
- 166 adults
- Comparison
- ESP block vs thoracic paravertebral block
- Erector spinaen = 83
- Paravertebraln = 83reference
- Primary endpoint
- Cumulative sufentanil dose and pain intensity (11-point scale); non-inferiority margins 5 μg and 1 point
- Follow-up
- 24 h
Methodological detailsnon-inferiority
- Non-inferiority
Primary result
Cumulative sufentanil dose
Median difference
5 μg
95% CI 0–10
P < 0.001
By group
Erector spinae vs Paravertebral
median difference 5 μg (95% CI 0–10); P < 0.001
Non-inferiority margin 5 as printed, not drawn
As reported in the abstract
Further findings
Median
| Outcome | Erector spinae | Paravertebral | Median difference (95% CI) | P value | |
|---|---|---|---|---|---|
| Pain intensity (11-point scale; co-primary)Non-inferiority p; margin 1 point | 1.5 (IQR [range] 1.0-2.0 [0.0-5.3]) | 2.0 (IQR [range] 1.0-2.5 [0.0-6.0]) | 0.3 (0.0–0.5) | P < 0.001 | |
| −0.200.20.40.6Difference (linear scale) |
- Pain intensity (11-point scale; co-primary): non-inferiority margin 1 point; ESP non-inferior
Safety
- Adverse events did not differ between groups
Original publication
A randomised controlled trial of the non‐inferiority of erector spinae plane block vs. thoracic paravertebral block for laparoscopic nephro‐ureterectomy. Anaesthesia. Published 4 January 2023. doi:10.
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