Cardiothoracic & vascular anaesthesia
A Randomized Trial of Intravenous Amino Acids for Kidney Protection
Primary resultResult — go to the resultRelative risk 0.85 95% CI 0.77–0.94Authors' conclusion
Among adult patients undergoing cardiac surgery, infusion of amino acids reduced the occurrence of AKI.
Study context
- Population
- Adults scheduled for cardiac surgery with cardiopulmonary bypass
- Participants
- 3,511 adults · 22 centres · 3 countries
- Comparison
- IV amino acids vs placebo
- Amino acidn = 1,759
- Placebon = 1,752reference
- Primary endpoint
- Acute kidney injury (AKI) (KDIGO creatinine criteria)
Methodological detailsmultinational, double-blind, placebo-controlled
- Multinational
- Double-blind
- Placebo-controlled
Primary result
As reported in the abstract
Relative risk
0.85
95% CI 0.77–0.94
P = 0.002
Events by treatment group
Amino acid vs Placebo
RR 0.85 (95% CI 0.77–0.94); P = 0.002
Secondary outcomes
| Outcome | Amino acid | Placebo | RR (95% CI) | |
|---|---|---|---|---|
| Stage 3 AKI | 1.6% | 3.0% | 0.56 (0.35–0.87) | |
| 0.20.5125Relative risk (log scale) |
Kidney-replacement therapy
Other secondary outcomes
- No substantial differences between groups
Safety
Adverse events
- No substantial differences between groups
Original publication
A Randomized Trial of Intravenous Amino Acids for Kidney Protection. N Engl J Med. Published 12 June 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →