Cardiothoracic & vascular anesthesia
Low-Dose Postoperative Amino Acid Infusion and Kidney Protection After Cardiac Surgery: A Before-and-After Observational Cohort Study
Authors' conclusion
Postoperative amino acids are effective in reducing AKI in a real-world setting.
Study context
- Population
- Adults undergoing cardiac surgery, intensive care unit (ICU)
- Participants
- 520 adults
- Exposure
- Amino acid vs Ringer lactate
- Amino acidn = 373
- Ringer lactaten = 147reference
- Outcome
- AKI by KDIGO criteria (stages 1, 2 and 3)
Methodological detailsconsecutive patients, multivariable analysis
- Consecutive patients
- Multivariable analysis
Main finding
As reported in the abstract
Overall incidence of AKI
P = 0.012
Observational data: associations, not effects.
Further findings
Acute kidney injury (AKI) after adjustment for potential confounders (multivariate analysis)
- Amino acids remained associated with a reduction in the overall incidence of AKI
Original publication
Low-Dose Postoperative Amino Acid Infusion and Kidney Protection After Cardiac Surgery: A Before-and-After Observational Cohort Study. J Cardiothorac Vasc Anesth. Published 27 March 2026. doi:10.
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