Cardiothoracic & vascular anesthesia
Center-mediated Differences in Postoperative Acute Kidney Injury Rates: A Post Hoc Analysis of the PROTECTION Trial
Primary result · CSA-AKI with AA, corrected for center effectResult — go to the resultRelative risk 0.79Authors' conclusion
Taking into account such center effects, however, AA therapy remained independently associated with CSA-AKI prevention.
Study context
- Population
- Adults undergoing cardiac surgery enrolled in the PROTECTION trial
- Comparison
- High-rate centers vs low-rate centers of cardiac surgery-associated acute kidney injury (CSA-AKI); Amino acid (AA) vs no AA corrected for center effect
- Primary endpoint
- Cardiac surgery-associated AKI (CSA-AKI)
Methodological detailsmulticentre
- Multicentre
Primary result
CSA-AKI with AA, corrected for center effect
Relative risk
0.79
As reported in the abstract
Further findings
Preoperative patient characteristics, HR-C vs low-rate centers
- HR-C patients older, lower LV ejection fraction and hemoglobin, more NYHA class III–IV, hypertension, previous MI, DM, peripheral vascular disease, more myocardial revascularization
- P = 0.001
Intraoperative management, HR-C vs low-rate centers
- HR-C: longer aortic cross-clamp time, higher temperature on CPB, less diuretics and hemofiltration, more norepinephrine
Original publication
Center-mediated Differences in Postoperative Acute Kidney Injury Rates: A Post Hoc Analysis of the PROTECTION Trial. J Cardiothorac Vasc Anesth. Published 22 October 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →