Cardiac arrest & resuscitation
A retrospective, multi-agency ‘target trial emulation’ for the comparison of post-resuscitation epinephrine to norepinephrine
Authors' conclusion
In this multi-agency target trial emulation, the use of a post-resuscitation epinephrine infusion was not associated with increased odds of rearrest in comparison to the use of a norepinephrine infusion.
Study context
- Population
- Adults (18–80 years) with non-traumatic OHCA and a documented prehospital post-ROSC vasopressor infusion, ESO Data Collaborative 2018–2022309 EMS agencies
- Participants
- 1,893 adults
- Exposure
- Post-ROSC epinephrine infusion vs norepinephrine infusion
- Epinephrinen = 1,010
- Norepinephrinen = 883reference
- Outcome
- Rearrest and mortality
Methodological detailstarget trial emulation, multi-agency, multivariable logistic regression, Cox regression
- Target trial emulation
- Multi-agency
- Multivariable logistic regression
- Cox regression
Main finding
As reported in the abstract
No association between vasopressor agent and mortality in adjusted analyses, aOR
1.00
0.59, 1.69
Observational data: associations, not effects.
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
A retrospective, multi-agency ‘target trial emulation’ for the comparison of post-resuscitation epinephrine to norepinephrine. Resuscitation. Published 4 April 2024. doi:10.
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