Cardiac arrest & resuscitation
Lidocaine Versus Amiodarone in Patients With Shockable Out-of-Hospital Cardiac Arrest: A Target Trial Emulation
Main findingResult — go to the resultAdjusted percentage point difference 2.8% 95% CI −0.6 to 6.2Authors' conclusion
No statistically significant difference in survival or favorable neurologic outcome was observed between lidocaine and amiodarone; however, the wide CIs cannot exclude a clinically meaningful benefit for lidocaine.
Study context
- Population
- Adults with nontraumatic out-of-hospital cardiac arrest (OHCA) and an initial shockable rhythm after at least three defibrillation attempts, Resuscitation Outcomes Consortium Cardiac Epidemiologic Registry 3 (2011–2015), North America
- Participants
- 2,451 adults
- Exposure
- Lidocaine vs amiodarone
- Lidocainen = 987
- Amiodaronen = 1,464reference
- Outcome
- Survival to hospital discharge
Methodological detailsinverse probability weighting, multicentre registry, prospectively collected
- Inverse probability weighting
- Multicentre registry
- Prospectively collected
Main finding
As reported in the abstract
Adjusted percentage point difference
2.8%
95% CI −0.6 to 6.2
Events by group
Lidocaine vs Amiodarone
adjusted percentage point difference 2.8% (95% CI −0.6 to 6.2)
Observational data: associations, not effects.
Secondary outcomes
| Outcome | Lidocaine | Amiodarone | Adjusted difference (95% CI) | |
|---|---|---|---|---|
| Favorable neurologic outcome at discharge (modified Rankin scale score of 3 or less), key secondaryEstimated probability | 17.7% | 16.2% | 1.5% (−1.5 to 4.5) | |
| −20246Difference (linear scale) |
Original publication
Lidocaine Versus Amiodarone in Patients With Shockable Out-of-Hospital Cardiac Arrest: A Target Trial Emulation. Crit Care Med. Published 15 July 2026. doi:10.
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