Cardiac arrest & resuscitation
Amiodarone dose in patients with shockable out-of-hospital cardiac arrest
Main finding · ROSC at ED arrival (estimated probability)Result — go to the resultAdjusted probability difference 6.6% CI 0.9–12.3Authors' conclusion
In patients with shockable OHCA who received 5 or more defibrillation attempts, a dose of amiodarone 300 mg was associated with a similar survival compared with a total dose of amiodarone 450 mg.
Study context
- Population
- Patients with shockable out-of-hospital cardiac arrest (OHCA) who received 5 or more defibrillation attempts, Resuscitation Outcomes Consortium Cardiac Epidemiologic Registry (2011–2015)
- Participants
- 910 patients
- Exposure
- Amiodarone 300 mg vs 450 mg
- Amiodarone 300 mgn = 426
- Amiodarone 450 mgn = 484reference
- Outcome
- ROSC at ED arrival (estimated probability)
Methodological detailsinverse probability weighting, multiple logistic regression
- Inverse probability weighting
- Multiple logistic regression
Main finding
As reported in the abstract
Adjusted probability difference
6.6%
CI 0.9–12.3
P = 0.0234
By group
Amiodarone 300 mg vs Amiodarone 450 mg
adjusted probability difference 6.6% (CI 0.9–12.3); P = 0.0234
Observational data: associations, not effects.
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Amiodarone dose in patients with shockable out-of-hospital cardiac arrest. Resuscitation. Published 11 February 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →