Cardiac arrest & resuscitation
Amiodarone after conversion from a non-shockable to a shockable rhythm in out-of-hospital cardiac arrest: A propensity score-matched analysis from the German resuscitation registry
Main finding · Survival to hospital dischargeResult — go to the resultOR for survival to hospital discharge 1.58 95% CI 1.18–2.12Authors' conclusion
In OHCA patients with an initial non-shockable rhythm who subsequently converted to a shockable rhythm, amiodarone administration was associated with improved short-term and long-term survival, but not with a statistically significant improved favourable neurological outcome. Future controlled studies might define the proper (earlier) time of amiodarone administration.
Study context
- Population
- Adult patients with non-traumatic out-of-hospital cardiac arrest (OHCA), having an initial non-shockable rhythm and subsequently received at least two defibrillationspatients included, after propensity-score matching, 1843 patients remained in each group · received amiodarone 3,181 · did not receive amiodarone 2,354
- Participants
- 5,535 patients
- Exposure
- Patients who received amiodarone during resuscitation and those who did not
- Amiodaronen = 1,843
- No amiodaronen = 1,843reference
- Outcome
- Survival to hospital discharge
- Follow-up
- Hospital discharge
Methodological detailsPropensity-score-matched patient pairs (1:1), German Resuscitation Registry
- Propensity-score-matched patient pairs (1:1)
- German Resuscitation Registry
Main finding
As reported in the abstract
OR for survival to hospital discharge
1.58
95% CI 1.18–2.12
By group
Amiodarone vs No amiodarone
OR for survival to hospital discharge 1.58 (95% CI 1.18–2.12)
Observational data: associations, not effects.
Secondary outcomes
| Outcome | Amiodarone | No amiodarone | Estimate | |
|---|---|---|---|---|
| Hospital admission with return of spontaneous circulation (ROSC)Secondary outcome | 26.7% | 23.0% | OR for hospital admission with ROSC 1.22 (95% CI 1.05–1.42) | |
| 24-h survivalSecondary outcome | 21.4% | 14.7% | OR for 24-h survival 1.58 (95% CI 1.33–1.87) | |
| Favourable neurological outcome at hospital dischargeSecondary outcome | 3.7% | 2.9% | OR for favourable neurological outcome 1.31 (95% CI 0.91–1.89) | |
| 0.512Ratio (log scale) |
Original publication
Amiodarone after conversion from a non-shockable to a shockable rhythm in out-of-hospital cardiac arrest: A propensity score-matched analysis from the German resuscitation registry. Resuscitation. Published 6 October 2026. doi:10.
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