Cardiac arrest & resuscitation
The association between initial defibrillation dose and outcomes following adult out-of-hospital cardiac arrest resuscitation: A retrospective, multi-agency study
Authors' conclusion
Initial defibrillation dose was not associated with outcome in this nationwide cohort.
Study context
- Population
- Adults (18–80 years) with non-traumatic out-of-hospital cardiac arrest (OHCA) and initially shockable ECG rhythm, ESO Data Collaborative (2018–2022)12,160 linked to manufacturer
- Participants
- 21,121 adults
- Exposure
- Initial defibrillation dose
- Biphasic truncated exponential (BTE)n = 7,240
- Rectilinear biphasic (RLB)n = 4,920
- Outcome
- ROSC
Methodological detailsmulti-agency, nationwide, multivariable logistic regression
- Multi-agency
- Nationwide
- Multivariable logistic regression
Main finding
As reported in the abstract
ROSC per 1 J/kg increase in initial defibrillation dose
AOR for ROSC (CI)
BTEn = 7,240
0.97(0.92–1.01)
RLBn = 4,920
1.00(0.92–1.09)
All21,121
1.01(0.98–1.04)
Per 1 J/kg increase in initial defibrillation dose, as printed
Observational data: associations, not effects.
Secondary outcomes
| Outcome | aOR for survival to discharge (CI) | |
|---|---|---|
| Survival to discharge per 1 J/kg increase in initial defibrillation doseBTE · n = 1,245 | 0.98 (0.87–1.10) | |
| Survival to discharge per 1 J/kg increase in initial defibrillation doseRLB · n = 775 | 0.89 (0.70–1.12) | |
| Survival to discharge per 1 J/kg increase in initial defibrillation doseAll · n = 2,981 | 1.00 (0.92–1.08) | |
| 0.512AOR for survival to discharge (log scale) |
Survival to discharge per 1 J/kg increase in initial defibrillation dose
- Defibrillation dose not associated with survival
Original publication
The association between initial defibrillation dose and outcomes following adult out-of-hospital cardiac arrest resuscitation: A retrospective, multi-agency study. Resuscitation. Published 23 January 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →