A single-centre, randomised comparison of the performance and safety of a novel mechanomyography sensor with electromyography
Authors' conclusion
The TOF3D mechanosensor was not less precise than electromyography during baseline.
Study context
- Population
- Anaesthetised adult patients receiving rocuronium 0.45 mg kg-1 i.v. then sugammadex 2 mg kg-1 i.v.
- Participants
- 33 devices on opposite arms
- Exposure
- Mechanomyography vs electromyography
- Outcome
- Precision (repeatability coefficient) of TOF ratio measurement; noninferior if repeatability coefficient did not exceed a margin of 0.01
- Follow-up
- Baseline and full recovery
Methodological detailssingle-centre, randomised device placement, noninferiority
- Single-centre
- Randomised device placement
- Noninferiority
Main finding
As reported in the abstract
TOF ratio precision
Mechanomyography vs ElectromyographyMedian difference (95% CI)
Baseline; covered the acceptable margin
0.039(0.007–0.042)
After recovery to TOF ratio >0.9; did not cover the margin
0.052(0.047–0.076)
Non-inferiority margin 0.01 as printed, not drawn
Observational data: associations, not effects.
Original publication
A single-centre, randomised comparison of the performance and safety of a novel mechanomyography sensor with electromyography. Br J Anaesth. Published 7 January 2026. doi:10.
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