Respiratory failure & ventilation
A Study on the Diagnostic Accuracy of Tidal Volume-Diaphragmatic Contraction Velocity: A Novel Index for Weaning Outcome Prediction
Authors' conclusion
VVI effectively differentiates between weaning success and failure, shows a strong correlation with respiratory effort indices, and may enhance weaning protocols.
Study context
- Population
- Critical care patients undergoing a spontaneous breathing trial (SBT) for the first timeinception 30, validation 40
- Comparison
- Volume-velocity index (VVI) in weaning success vs failure
- Outcome
- VVI, validation cohort (n = 40)
Methodological detailsprospective, inception and validation cohorts, consecutive sampling, single tertiary academic ICU
- Prospective
- Inception and validation cohorts
- Consecutive sampling
- Single tertiary academic ICU
Performance
As reported in the abstract
Weaning success
840
interval 550–1220
Weaning failure
250
interval 225–302.5
P < 0.001
- AUC of VVI for predicting weaning success
- 0.92 (95% CI, 0.83-1)
Further findings
| Outcome | Successful weaning | Failures | P value |
|---|---|---|---|
| VVI (mL*cm/s), inception cohort (n = 30)VVI significantly higher in successful weaning | 764.76 ± 432.61 | 278 ± 183.66 | P < 0.001 |
Correlation of VVI with breathing effort indices, inception cohort
- ΔPes r
- 0.74
- ΔPes R2
- 0.55
- PTPes r
- 0.76
- PTPes R2
- 0.58
- Maximal inspiratory pressure (MIP) r
- 0.75
- MIP R2
- 0.55
- All p values less than 0.001
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
A Study on the Diagnostic Accuracy of Tidal Volume-Diaphragmatic Contraction Velocity: A Novel Index for Weaning Outcome Prediction. Crit Care Med. Published 1 April 2025. doi:10.
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