Ability of diastolic arterial pressure to better characterize the severity of septic shock when adjusted for heart rate and norepinephrine dose
Authors' conclusion
In patients receiving NE during early septic shock, VNERi demonstrated the strongest association with outcome compared to DAP, DAP/HR, and MAP/NE dose.
Study context
- Population
- Patients with septic shock receiving norepinephrine (NE), ANDROMEDA-SHOCK database
- Participants
- 424 patients
- Comparison
- Association with outcome of VNERi) vs diastolic arterial pressure (DAP), DAP/HR and mean arterial pressure (MAP)/NE dose
- Primary endpoint
- In-hospital mortality
Methodological detailspost-hoc analysis, multivariate model, Hemodynamic variables and initial NE doses recorded at randomization, within 4 h of septic shock diagnosis
- Post-hoc analysis
- Multivariate model
- Hemodynamic variables and initial NE doses recorded at randomization, within 4 h of septic shock diagnosis
Primary result
As reported in the abstract
In-hospital mortality
43%
Inverted J-shaped relationship between in-hospital mortality and VNERi, nadir point (mortality increased below)
6.7
Further findings
Vasopressor-free days and renal replacement therapy (RRT)-free days up to day 28
- Similar findings (VNERi strongest association)
Baseline hemodynamics at inclusion
- Median DAP, mmHg [IQR: 45-50]
- 52
- Median NE dose, µg/kg/min [IQR: 01-0.4]
- 0.2
Original publication
Ability of diastolic arterial pressure to better characterize the severity of septic shock when adjusted for heart rate and norepinephrine dose. Ann Intensive Care. Published 26 March 2025. doi:10.
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