Neuroanesthesia & neurocritical care
Acute Effects of Ketamine on Intracranial Pressure in Children With Severe Traumatic Brain Injury*
Authors' conclusion
In this retrospective, exploratory study, ICP did not increase following ketamine administration. In the setting of a guidelines-based protocol, ketamine was associated with a reduction in ICP during ICP crises.
Study context
- Population
- Children (1 month to 16 years) with severe traumatic brain injury (TBI) undergoing intracranial pressure (ICP) monitoring, 30-bed tertiary care children's hospital PICU22 received ketamine
- Participants
- 33 children
- Exposure
- ICP and cerebral perfusion pressure (CPP) after ketamine bolus vs baseline
- ICP crisis dosesn = Eighteen
- Outcome
- ICP and CPP after ketamine bolus vs baseline
Methodological detailsexploratory, single-centre
- Exploratory
- Single-centre
Main finding
As reported in the abstract
- Sedation doses: no significant difference in ICP or CPP from baseline
- ICP crisis doses (18 doses, 11 patients): ICP decreased and threshold-subtracted CPP rose
Observational data: associations, not effects.
Further findings
Patient characteristics, ketamine vs no ketamine
- Demographics, patient and injury characteristics similar
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Acute Effects of Ketamine on Intracranial Pressure in Children With Severe Traumatic Brain Injury*. Crit Care Med. Published 21 February 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →