Cardiac arrest & resuscitation
Acute Kidney Injury After Extracorporeal Cardiopulmonary Resuscitation for Out-of-Hospital Cardiac Arrest
Primary result · In-hospital mortalityResult — go to the resultOdds ratio 4.15 95% CI 3.05–5.66Authors' conclusion
This large cohort study revealed that AKI was commonly observed during the early phase after ECPR for OHCA and was associated with in-hospital mortality and unfavorable neurologic outcomes.
Study context
- Population
- Adults with out-of-hospital cardiac arrest (OHCA) of presumed cardiac etiology who received extracorporeal cardiopulmonary resuscitation (ECPR) and were admitted to the ICU, 36 ICUs in Japan, 2013–2018
- Participants
- 943 adults · 36 ICUs
- Comparison
- Acute kidney injury (AKI) vs no AKI
- AKIn = 631
- Primary endpoint
- In-hospital mortality
Primary result
As reported in the abstract
Odds ratio
4.15
95% CI 3.05–5.66
P < 0.001
AKI vs No AKI
OR 4.15 (95% CI 3.05–5.66); P < 0.001
Secondary outcomes
| Outcome | OR (95% CI) | P value | |
|---|---|---|---|
| Unfavourable neurologic outcome (CPC 3-5 at discharge)Multivariable analysis | 3.43 (2.42–4.87) | P < 0.001 | |
| 0.20.5125Odds ratio (log scale) |
- AKI incidence · 4 days after ICU admission
- 66.9% · 631
Factors associated with AKI
- Age, time course, pH at hospital arrival, creatinine at hospital admission and BP on ICU admission significantly associated with AKI
Original publication
Acute Kidney Injury After Extracorporeal Cardiopulmonary Resuscitation for Out-of-Hospital Cardiac Arrest. Crit Care Med. Published 12 November 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →