Cardiac arrest & resuscitation
Organ donation after extracorporeal cardiopulmonary resuscitation: a nationwide retrospective cohort study
Authors' conclusion
This nationwide study reveals that lung graft survival was lower in recipients from ECPR-treated donors
Study context
- Population
- Deceased organ donors with at least one episode of cardiac arrest, Japan, July 17, 2010–August 31, 2022370 brain death and 160 circulatory death donors
- Exposure
- Extracorporeal cardiopulmonary resuscitation (ECPR) vs non-ECPR donors after cardiac arrest
- Outcome
- Timeframes of donor management and long-term graft outcomes of recipients
Methodological detailsnationwide, Japan Organ Transplant Network database, Patients undergoing extracorporeal membrane oxygenation (ECMO) treatment were not eligible for legal diagnosis of brain death during the study period
- Nationwide
- Japan Organ Transplant Network database
- Patients undergoing ECMO treatment were not eligible for legal diagnosis of brain death during the study period
Main finding
As reported in the abstract
Brain death donors: interval from admission to organ procurement
P = 0.005
- Brain death donors: lung graft survival significantly lower in ECPR group; no significant differences in other organ graft survival
- log-rank test P = 0.009
Observational data: associations, not effects.
Further findings
Circulatory death donors: admission to procurement interval and graft survival · per_group values are proportions of circulatory death donors
- Duration of veno-arterial ECMO support after ECPR
- 3 · median · days
Circulatory death donors: admission to procurement interval and graft survival
- No significant differences between ECPR and non-ECPR groups
Number of organs donated
- Similar between ECPR and non-ECPR groups, regardless of brain or circulatory death
Original publication
Organ donation after extracorporeal cardiopulmonary resuscitation: a nationwide retrospective cohort study. Crit Care. Published 13 May 2024. doi:10.
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